Evaluation of Retinal Structure and Optic Nerve Function Changes in Multiple Sclerosis: Longitudinal Study with 1-Year Follow-Up

Table 5

Comparison of GCIPL and RNFL thickness between RRMS and SPMS eyes.

Variable	n	RRMS	n	SPMS
Mean ± standard deviation
GCIPL
Mean	42	73.19 ± 10.32	12	62.83 ± 7.31	0.002^a
Superior	42	73.64 ± 10.96	12	62.25 ± 8.50	0.002^b
Superonasal	42	73.81 ± 11.98	12	61.17 ± 9.16	0.002^a
Inferonasal	42	73.14 ± 12.56	12	60.25 ± 7.26	0.003^a
Inferior	42	71.98 ± 10.95	12	60.17 ± 4.93	0.001^a
Inferotemporal	42	73.98 ± 9.96	12	64.33 ± 6.72	0.003^a
Superotemporal	42	73.29 ± 9.22	12	63.67 ± 8.32	0.002^b
RNFL
Mean	42	91.79 ± 13.88	12	76.92 ± 7.00	<0.001^b
Superior	42	119.43 ± 22.02	12	102.58 ± 16.50	0.018^b
Nasal	42	69.33 ± 11.05	12	64.08 ± 7.93	0.132^b
Inferior	42	115.88 ± 19.64	12	90.67 ± 10.22	<0.001^a
Temporal	42	61.93 ± 17.42	12	50.42 ± 10.93	0.035^b

GCIPL: ganglion cell inner plexiform layer; RNFL: retinal nerve fiber layer, RRMS: relapsing-remitting multiple sclerosis; SPMS: secondary progressive multiple sclerosis. ^aMann–Whitney test, ^bT-independent test.