Regional Differences in Susceptibility to Hypoxic-Ischemic Injury in the Preterm Brain: Exploring the Spectrum from White Matter Loss to Selective Grey Matter Injury in a Rat Model

Figure 1

Periventricular white matter loss following hypoxia-ischemia (HI) in postnatal day 6 (P6) rats. Seventy-two hours following HI at P6, myelin basic protein (MBP) is significantly depleted in the hemisphere ipsilateral to carotid ligation. Representative photomicrographs show MBP in hemispheres both ipsilateral (a₁–d₁) and contralateral (a₂–d₂) to carotid ligation in animals with Grade 0 MBP loss (no discernable white matter injury, a₁-a₂), Grade 1 MBP loss (mild white matter injury, b₁-b₂), Grade 2 MBP loss (moderate white matter injury, c₁-c₂), and Grade 3 MBP loss (severe white matter injury, d₁-d₂). Histogram shows average percent change in MBP for each group (e).