Neural Plasticity

Gene-Environment Interactions in Neurodevelopmental Disorders


Status
Published

1University of Bordeaux, Talence, France

2Centre National de la Recherche Scientifique, Toulouse Cedex, France

3Swiss Federal Institute of Technology Zurich (ETH), Zurich, Switzerland


Gene-Environment Interactions in Neurodevelopmental Disorders

Description

Several lines of evidence have demonstrated the importance of gene-environment interactions in the etiopathology of most disorders of the nervous system. This issue is of crucial relevance for developmental pathologies, because of the stronger plasticity of the developing brain and its critical responsiveness to environmental changes. Indeed, a large body of human and animal data has demonstrated that environmental stimulation/deprivation can, respectively, ameliorate or exacerbate the symptoms of a variety of developmental diseases. Furthermore, increasing attention has been recently paid to the interactive contribution of genetic and environmental risk factors to the etiopathology of neurodevelopmental disorders.

We invite investigators to contribute original research as well as review articles on the impact of gene-environment interactions in animal models of all major developmental disorders. These will include autism spectrum disorders, Fragile X, Rett, Tourette, and Down syndromes, and attention deficit hyperactivity disorder and schizophrenia. Human studies on the combined effects of genetic and environmental factors will also be included, trying to parallel as far as possible the animal research selected for the issue. All genetic and environmental factors relevant to developmental pathologies will be considered, including, for example, nutritional manipulations, stress, immunological changes, environmental enrichment, physical exercise, and social and maternal deprivation.

Potential topics include but are not limited to the following:

  • Environmental insults as risk factors in genetically induced developmental pathologies
  • Environmental therapies for neurodevelopmental disorders
  • Factors critically affecting the role of gene-environment interactions: timing of the exposure, subjects ‘characteristics, and specific nature of the manipulations

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 8361290
  • - Research Article

Social Isolation Alters Social and Mating Behavior in the R451C Neuroligin Mouse Model of Autism

E. L. Burrows | A. F. Eastwood | ... | A. J. Hannan
  • Special Issue
  • - Volume 2017
  • - Article ID 9272804
  • - Editorial

Gene-Environment Interactions in Neurodevelopmental Disorders

Susanna Pietropaolo | Wim E. Crusio | Joram Feldon
  • Special Issue
  • - Volume 2016
  • - Article ID 3597209
  • - Review Article

Neuroinflammation in Autism: Plausible Role of Maternal Inflammation, Dietary Omega 3, and Microbiota

Charlotte Madore | Quentin Leyrolle | ... | Sophie Layé
  • Special Issue
  • - Volume 2016
  • - Article ID 2173748
  • - Review Article

Gene × Environment Interactions in Schizophrenia: Evidence from Genetic Mouse Models

Paula Moran | Jennifer Stokes | ... | Colm O’Tuathaigh
  • Special Issue
  • - Volume 2016
  • - Article ID 2734915
  • - Research Article

Environmental Enrichment Therapy for Autism: Outcomes with Increased Access

Eyal Aronoff | Robert Hillyer | Michael Leon
  • Special Issue
  • - Volume 2016
  • - Article ID 4235898
  • - Review Article

Where Environment Meets Cognition: A Focus on Two Developmental Intellectual Disability Disorders

I. De Toma | L. Manubens Gil | ... | M. Dierssen
  • Special Issue
  • - Volume 2016
  • - Article ID 5346161
  • - Research Article

Early Social Enrichment Improves Social Motivation and Skills in a Monogenic Mouse Model of Autism, the Oprm1−/− Mouse

Luciana Garbugino | Eleonora Centofante | Francesca R. D’Amato
Neural Plasticity
 Journal metrics
Acceptance rate45%
Submission to final decision84 days
Acceptance to publication41 days
CiteScore3.330
Impact Factor3.591
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