White Matter Microstructural Alterations over the Year after Acute Ischemic Stroke in Patients with Baseline Impaired Cognitive Functions

Table 4

WM tracts with significantly less KFA and MK at 1 year compared with baseline in longitudinal analysis.

Parameters	Index	Voxels	Peak MNI coordinates			P	Major tracts^a
			X	Y	Z
AIS (1 year < baseline)
KFA	1	104,046	−8	−22	27	0.002	SLF, GCC, BCC, SCC, CG, ATR, PTR, ALIC, PLIC, RLIC, SS, FX, UF, CST
MK	1	19,675	−12	−29	25	0.005	SLF, GCC, BCC, SCC, SOF, ATR, ALIC, RLIC, CST
	2	10,902	34	−18	25	0.005	SLF, CG, PLIC
	3	2,557	1	−17	18	0.005	FX
	4	258	−40	−40	−9	0.010	SS
	5	250	−32	−65	3	0.015	PTR
PSCI (1 year < baseline)
KFA	1	96,165	−5	−13	27	0.002	SLF, GCC, BCC, SCC, CG, ATR, PTR, ALIC, PLIC, RLIC, SS, FX, UF, CST
MK	1	17,936	1	9	21	0.005	SLF, GCC, BCC, SCC, CG, ATR, PTR, ALIC, PLIC, RLIC, SS, SOF, FX, CST
NCI (1 year < baseline)
KFA	1	46,526	9	22	−5	0.002	SLF, GCC, BCC, SCC, CG, ATR, PTR, ALIC, PLIC, RLIC, SS, FX, CST
MK	1	32,281	1	26	−1	0.005	SLF, GCC, BCC, SCC, CG, ATR, ALIC, PLIC, RLIC, SOF, CST
PSCI < NCI (two-way repeated measures ANOVA)
KFA	1	645	12	−36	25	0.005	BCC, SCC, PTR
	2	540	−20	−35	−11	0.005	CG, SS, PLIC, RLIC
	3	216	−13	29	−11	0.005	ATR
	4	191	−35	−29	31	0.005	SLF
	5	172	18	15	2	0.020	ALIC, FX
	6	97	18	25	22	0.010	GCC
MK	1	14,384	−31	3	21	0.005	SLF, GCC, BCC, SCC, ATR, PTR, SOF, ALIC, PLIC, RLIC, CG, SS

Abbreviations: MNI, Montreal Neurological Institute; SLF, superior longitudinal fasciculus; GCC, genu of corpus callosum; BCC, body of corpus callosum; SCC, splenium of corpus callosum; CG, cingulum; ATR, anterior thalamic radiation; PTR, posterior thalamic radiation; ALIC, anterior limb of internal capsule; PLIC, posterior limb of internal capsule; RLIC, retrolenticular part of internal capsule; SS, sagittal stratum; FX, fornix; UF, uncinate fasciculus; CST, corticospinal tract; SOF, superior fronto-occipital fasciculus. P: threshold-free cluster enhancement, FWE-corrected. ^aJHU white-matter tractography atlas.