White Matter Microstructural Alterations over the Year after Acute Ischemic Stroke in Patients with Baseline Impaired Cognitive Functions

Table 3

WM tracts showed significant differences in KFA and MK between groups in TBSS analysis.

Parameters	Index	Voxels	Peak MNI coordinates			P	Major tracts^a
			X	Y	Z
AIS (1 year) < HC (1 year)
KFA	1	65,037	2	25	12	0.002	SLF, GCC, BCC, SCC, CG, ATR, PTR, ALIC, PLIC, RLIC, SS, FX
MK	1	26,926	33	−7	21	0.005	SLF, GCC, BCC, SCC, CG, ATR, ALIC, PLIC
PSCI (1 year) < NCI (1 year)
KFA	1	962	0	−36	15	0.008	SCC, PTR, RLIC, CG, SS
	2	418	−41	−23	30	0.002	SLF
	3	243	−15	3	33	0.012	BCC
	4	66	10	−45	27	0.022	CG
	5	23	−21	32	15	0.034	ATR
MK	1	148	−21	−6	19	0.020	SOF, ATR, ALIC
	2	51	−35	−24	−2	0.015	RLIC
	3	50	−31	−66	1	0.015	PTR
	4	32	−10	20	16	0.035	GCC
	5	26	−30	−23	40	0.025	SLF

Abbreviations: MNI, Montreal Neurological Institute; SLF, superior longitudinal fasciculus; GCC, genu of corpus callosum; BCC, body of corpus callosum; SCC, splenium of corpus callosum; CG, cingulum; ATR, anterior thalamic radiation; PTR, posterior thalamic radiation; ALIC, anterior limb of internal capsule; PLIC, posterior limb of internal capsule; RLIC, retrolenticular part of internal capsule; SS, sagittal stratum; FX, fornix; SOF, superior fronto-occipital fasciculus. P: threshold-free cluster enhancement, FWE-corrected. ^aJHU white-matter tractography atlas.