Reduced Expression of Voltage-Gated Sodium Channel Beta 2 Restores Neuronal Injury and Improves Cognitive Dysfunction Induced by Aβ1-42

Figure 5

Effects of Aβ1-42 and Navβ2 on the cognitive and memory function in Aβ1-42-treated mice. (a) Quantitative error times in passive avoidance experiment of mice after introduction of different lentivirus vectors (). Versus two different treatment groups, . (b) Quantitative incubation period in passive avoidance experiment of mice after introduction of different lentivirus vectors (). Versus two different treatment groups, . (c) Object recognition index (RI) in novel object recognition test of mice after introduction of different lentivirus vectors (). Versus two different treatment groups, . (d) Object discrimination index (DI) in novel object recognition test of mice after introduction of different lentivirus vectors (). Versus two different treatment groups, . Normal group: normal farmed mice without treatment; DMSO: normal farmed mice injected with DMSO in bilateral hippocampal; empty: empty viral vector; OE: overexpression; si: small interfering.

(a)

(b)

(c)

(d)