Role of Astrocytic Dysfunction in the Pathogenesis of Parkinson’s Disease Animal Models from a Molecular Signaling Perspective

Figure 3

NF-κB/JWA/ARL6ip5 signaling pathway in PD. Both DNA damage and abnormal activation of the known mediator of tissue damage and inflammation NF-κB have been implicated in oxidative damage. The ARL6ip5 downregulates IKKβ expression inhibiting NF-κB signaling pathway activation. NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells; ARL6ip5: ADP-ribosylation-like factor 6 interacting protein 5.