Aging Alters Olfactory Bulb Network Oscillations and Connectivity: Relevance for Aging-Related Neurodegeneration Studies

Figure 5

(a) Placement of the stimulation-recording electrodes at the Schaffer collateral-CA1 stratum pyramidal synapses in anesthetized mice (top panel), and a typical waveform spaghetti curves where the latency to peak negative deflection of fEPSPs is within 6-10 ms and the maximum amplitude between 1500 μV and 2500 μV. (b) Collective I/O curves of stimulation voltage and fEPSP slope (top panel) or PSA (bottom panel) values relative to baseline are plotted for young (black, ) and aged (green ) C57BL/6 mice. There was no significant alteration in baseline synaptic response, (c) A decline in synaptic response to HFS was observed in normalized EPSP and PSA values and was maintained throughout the recording session. No difference was observed in the average wave form during the 30 min baseline interval prior tetanisation, whereas smaller waveform was observed in aged mice during 0-30 min and 60-90 min posttetanisation. Data are presented as (%). Line above indicates statistical significance between groups, repeated ANOVA.

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