Systematic Analysis of Environmental Chemicals That Dysregulate Critical Period Plasticity-Related Gene Expression Reveals Common Pathways That Mimic Immune Response to Pathogen

Figure 5

Clustering of chemical pathway enrichments identifies antimicrobial and inflammatory clusters. Hierarchical clustering (Ward D method) on the negative log Padj values of Gene Ontology (GO) Biological Process (BP) and LINCS ligand enrichment analysis revealed two clusters of chemicals. Cluster A (29 chemicals) contains few inflammatory pathway enrichments and 9 of the 10 antimicrobials in the set of 50 chemicals examined, whereas Cluster B contains the majority of enrichments for response to pathogen, inflammation, immune cell chemotaxis, and IL-1/TNF-α. See Supplementary Figure 1 for detailed enrichment information.