MMP-9 Contributes to Dendritic Spine Remodeling Following Traumatic Brain Injury

Figure 2

Time-dependent changes in dendritic spines shape after controlled cortical impact (CCI). (a) Spine shape parameters: A: spine area; B: spine length; C: head width; B/C: length/width ratio. (b) Spine area calculated in the ipsi- and contralateral cortex and hippocampus of C57Bl6/J mice, 1 and 7 days after CCI and sham procedures. (c) Head width calculated in the ipsi- and contralateral cortex and hippocampus of C57Bl6/J mice, 1 and 7 days after CCI and sham procedures. (d) Spine length calculated in the ipsi- and contralateral cortex and hippocampus of C57Bl6/J mice, 1 and 7 days after CCI and sham procedures. (e) Length/width ratio calculated in the ipsi- and contralateral cortex and hippocampus of C57Bl6/J mice, 1 and 7 days after CCI and sham-operated animals. Data are presented as . Statistical analysis was carried out using one-way ANOVA followed by Tukey’s post hoc test. Asterisks indicate statistical significance from the CCI and sham groups, respectively. ; ; ; .

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