Research Article
The Modulatory Effect of Cerebrovascular Burden in Response to Cognitive Stimulation in Healthy Ageing and Mild Cognitive Impairment
Table 6
Effect of WML-by-timepoint interaction on extracted functional networks.
| Cluster level FWE | Cluster extent (voxels) | score at local maximum | Hemisphere | Brodmann area | Talairach coordinates | Brain region | | | |
| Healthy controls: positive interaction between vascular burden group and timepoint on functional connectivity of the posterior DMN | 0.006 | 462 | 4.65 | R | 7 | 28 | -57 | 54 | Precuneus | | | 4.29 | R | 7 | 34 | -56 | 54 | Superior parietal lobule | | | 3.92 | R | 7 | 18 | -48 | 54 | Precuneus | | | 3.54 | R | 40 | 32 | -42 | 52 | Inferior parietal lobule | | | 3.46 | R | 7 | 20 | -63 | 57 | Superior parietal lobule | | | 3.37 | R | 40 | 36 | -44 | 54 | Inferior parietal lobule | | | 3.18 | R | 40 | 36 | -50 | 47 | Inferior parietal lobule | 0.031 | 351 | 4.4 | L | 7 | -26 | -56 | 47 | Superior parietal lobule | | | 3.98 | L | 40 | -40 | -36 | 50 | Inferior parietal lobule | | | 3.9 | L | 7 | -18 | -50 | 43 | Precuneus | | | 3.66 | L | 40 | -28 | -36 | 53 | Postcentral gyrus | | | 3.5 | L | 40 | -36 | -40 | 55 | Inferior parietal lobule | | | 2.93 | L | 7 | -22 | -51 | 58 | Superior parietal lobule | | | 2.64 | L | 7 | -34 | -54 | 52 | Superior parietal lobule | MCI: positive interaction between vascular burden group and timepoint on functional connectivity of the salience network | 0.036 | 358 | 3.54 | R | | 34 | -13 | 12 | Claustrum | | | 3.36 | R | 13 | 38 | -3 | 13 | Insula | | | 3.33 | R | 13 | 38 | 9 | 16 | Insula | | | 3.49 | R | | 34 | 10 | 7 | Claustrum | | | 2.98 | R | | 34 | 4 | 9 | Claustrum | | | 2.79 | R | 13 | 32 | -22 | 20 | Insula | All: interaction between vascular burden and timepoint on functional connectivity of the posterior DMN in participants with low CR | 0.013 | 277 | 3.83 | R | 24 | 16 | 4 | 37 | Cingulate gyrus | | | 3.77 | R | 24 | 4 | 2 | 37 | Cingulate gyrus | | | 3.50 | R | 24 | 18 | -13 | 43 | Cingulate gyrus |
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Note: only clusters surviving corrected threshold reported. FWE: family-wise error; R: right; L: left.
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