Environmental Enrichment Induces Changes in Long-Term Memory for Social Transmission of Food Preference in Aged Mice through a Mechanism Associated with Epigenetic Processes

Figure 4

(a) H3 acetylation on L14 in subregions of OFC for SC (open columns), EE (filled columns), PL-SC (dotted columns), and PL-EE (hatched columns) mice 1 hour after the learning phase. PL-SC did not differ from PL-EE mice. Only EE animals showed significant differences with respect to their controls in OFC areas; (one-way ANOVA (), post hoc analysis Holm-Sidak method, SC versus PL-SC and PL-SC versus PL-EE () for all subregions). MO: EE versus SC (), EE versus PL-EE (). LO: EE versus SC (), EE versus PL-EE (). VO: EE versus SC (), EE versus PL-EE (). DLO: EE versus SC (), EE versus PL-EE (). ; ; ; error bars = SEM. (b) Representative panel of histone H3 acetylation in DLO for SC, EE, PL-SC, and PL-EE mice 1 h after learning; scale bar: 50 μm.

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