Drosophila: An Emergent Model for Delineating Interactions between the Circadian Clock and Drugs of Abuse

Figure 3

Central and peripheral circadian regulation of metabolic function. Under normal conditions, the central circadian oscillator in the SCN is entrained by light and synchronizes peripheral oscillators. Meal timing can also entrain the liver oscillators. Environmental perturbations such as shift work, jet lag, sleep restriction, and substance abuse create misalignment between the SCN and the peripheral oscillators resulting in metabolic syndromes and disease.