Neural Plasticity

Review Article

Relationship between Insulin Levels and Nonpsychotic Dementia: A Systematic Review and Meta-Analysis

Table 2

Baseline subject characteristics (nonpsychotic dementia and HCs).


Names (IN) mmol/l	Age		Edu	Sex		Number		Nonpsychotic dementia		HC		Sample	State	Drug	value
Names (IN) mmol/l	Ex	HC	Edu	Men	Women	Ex	HC	Mean	s.d.	Mean	s.d.	Sample	State	Drug	value

Si-ling Liu, 2011 AD	72	72	11.2	34	19	23	30	—	—	—	—	Serum	Fast	—	H
Qin-yun Li, 2015 AD	77	75	10.1	126	120	126	120	11.78	6.6	6.28	3.36	Serum	Fast	No	H
Zong-yuan Wang, 2008 a AD L	70	72	—	—	—	14	12	5.7	6.9	4.5	3.5	Plasma	Fast	No	H
Zong-yuan Wang, 2008 b AD (MH)	70	72	—	—	—	9	12	10.3	9.8	4.5	3.5	Plasma	Fast	No	H
Zong-yuan Wang, 2008 c AD L	70	72	—	—	—	14	12	3.4	0.3	3.3	0.4	CSF	Fast	No
Zong-yuan Wang, 2008 d AD (MH)	70	72	—	—	—	9	12	2.4	0.2	3.3	0.4	CSF	Fast	No	L
Abimbola A. Akintola, 2015 multi	66	66	—	62	70	75	57	—	—	—	—	Plasma	Fast	No
Angela J. Hanson, 2016 AD	68	72	—	163	156	199	120	15.6	—	11.7	—	Plasma	Fast	—	H
J.K. Morris, 2016 AD L	71	72	17	22	29	14	37	8.73	7.8	4.19	3.8	Plasma	Fast	Yes	H
G. Stennis Watson, 2009 AD	76	74	15	13	22	16	19	8.2	4.3	8.9	4.8	Plasma	Fast	No
Robert Krikorian, 2012 MCI	71	68	15	—	—	11	12	14.4	6	16.9	6	—	Fast	No
E. Rönnemaa, B. Zethelius, and J. Sundelöf, 2009 multi	71	71	—	—	—	257	868	—	1.0	—	0.96	Plasma	Fast	Yes	H
Galit Weinstein, 2015 multi	47	47	—	2156	1782	215	3723	—	—	—	—	—	Fast	Yes	H
Jeffrey M. Burns, 2012 AD	75	73	16	59	50	48	61	8.4	5.4	7.2	4.6	Serum	Fast	—
Auriel A. Willette, 2015 a MCI	76	76	15	95	185	194	26	2.78	3.08	2.98	3.10	Plasma	Fast	—
Auriel A. Willette, 2015 AD b	76	76	15	95	185	60	26	2.41	1.46	2.98	3.10	Plasma	Fast	—
Amber S. Watts, 2013 AD	75	74	—	61	87	75	73	—	—	—	—	Serum	Fast	—
Josh D. Woolley, 2014 a AD	59	57	15	16	19	17	18	—	—	—	—	Serum	-3 min	—	H
Josh D. Woolley, 2014 b (bvFTD)	59	57	15	18	19	19	18	—	—	—	—	Serum	−30 min	—	H
Xiao-hong Sun, 2010 AD	—	—	—	32	58	45	44	12.36	8.627	6.541	9.120	Serum	Fast	—	H
Lu Zhang, 2011 a AD L	72	72	—	59	44	41	35	1.07	0.21	1.51	0.27	CSF	—	—	L
Lu Zhang, 2011 b AD MH	72	72	—	59	44	27	35	0.68	0.11	1.51	0.27	CSF	—	—	L
Wei-gang Liu, 2009 a AD L	71	71	—	66	59	31	70	7.9	2.0	6.8	2.5	—	Fast	—	H
Wei-gang Liu, 2009 b AD MH	71	71	—	66	59	24	70	8.0	2.4	6.8	2.5	—	Fast	—	H
Wei-gang Liu, 2009 c AD L	71	71	—	45	38	27	35	0.27	0.08	0.29	0.10	CSF	—	—
Wei-gang Liu, 2009 d AD MH	71	71	—	45	38	21	35	0.22	0.12	0.29	0.10	CSF	—	—	L
Gui-qing Chen, 2015 AD	78	78	7	94	81	95	80	9.758	7.42	6.384	5.89	Serum	Fast	—	H
Zhi-juan Wang, 2014 a AD	67	67	—	28	22	30	20	7.94	6.81	9.25	5.51	Serum	Fast	—
Zhi-juan Wang, 2014 b VD	67	67	—	29	23	30	20	7.89	6.55	9.25	5.51	Serum	Fast	—
Jun-shi Zhang, 2016 AD	76	76	—	47	39	43	43	11.79	6.62	6.25	3.34	Serum	Fast	—	H
Jin-geng Li, 2013 a AD L	73	73	7	39	46	18	30	10.667	10.51	6.793	14.75	—	Fast	—	H
Jin-geng Li, 2013 b AD M	73	73	7	39	46	20	30	9.203	5.36	6.793	14.75	—	Fast	—	H
Jin-geng Li, 2013 c AD H	73	73	7	39	46	17	30	9.324	7.48	6.793	14.75	—	Fast	—	H
Jin-geng Li, 2013 d AD (total)	73	73	7	39	46	55	30	9.718	10.31	6.793	14.75	—	Fast	—	H
Zhi-dong Yang, 2007a AD L	—	—	—	36	43	21	31	16.1	3.7	11.6	4.3	Plasma	Fast	—	H
Zhi-dong Yang, 2007 b AD MH	—	—	—	36	43	27	31	22.1	5.2	11.6	4.3	Plasma	Fast	—	H
Zhi-dong Yang, 2007 c AD L	—	—	—	36	43	21	31	0.98	0.33	1.12	0.31	CSF	Fast	—
Zhi-dong Yang, 2007 d AD MH	—	—	—	36	43	27	31	0.63	0.17	1.12	0.31	CSF	Fast	—	L
Hong-mei Yue, 2014 a MCI	72	72	10	—	—	116	76	19.90	1.62	11.15	1.60	Serum	Fast	—	H
Hong-mei Yue, 2014 b AD L	72	72	10	—	—	81	76	17.90	5.6	11.15	1.6	Serum	Fast	—	H
Hong-mei Yue, 2014 c AD M	72	72	10	—	—	72	76	27.08	1.6	11.15	1.6	Serum	Fast	—	H
Hong-mei Yue, 2014 d AD H	72	72	10	—	—	34	76	34.10	1.61	11.15	1.6	Serum	Fast	—	H
Liang-mi Li, 2015 a AD	73	73	—	117	103	80	70	7.94	0.83	8.23	1.04	Serum	Fast	—
Liang-mi Li, 2015 b VD	73	73	—	117	103	70	70	7.89	0.89	8.23	1.04	Serum	Fast	—
Qing-chun Xia, 2015 a AD L	70	70	—	27	63	34	30	30.29	20.00	20.15	20.50	Plasma	Fast	No	H
Qing-chun Xia, 2015 b AD MH	70	70	—	27	63	26	30	40.29	21.10	20.15	20.50	Plasma	Fast	No	H
Ran Song, 2015 VD	65	65	—	53	32	39	46	8.88	0.31	4.97	2.01	Serum	Fast	Yes	H
Yu-mei Yang, 2009 MCI	63	63	—	81	114	51	144	10.50	—	8.10	—	—	Fast	—	H
Xiao-lan Liu, 2008 VD	74	74	—	88	32	40	40	10.01	—	8.7	—	—	Fast	No
Rong-wei Zhang, 2008 a MVCI	73	73	—	56	38	37	34	13.5	1.4	10.40	1.2	Serum	Fast	—
Rong-wei Zhang, 2008 b VD	73	73	—	56	38	23	34	15.4	2.0	10.40	1.2	Serum	Fast	—	H
Bin-bin Zang, 2011 multi	76	76	—	33	27	30	30	6.42	0.58	5.53	1.03	Serum	Fast	—	H
Zhi-juan Wang, 2014 c AD	74	74	—	69	35	68	36	7.82	6.46	8.37	5.31	Serum	Fast	—
Hong-shan Pan, 2016 AD	69	69	—	50	40	45	45	7.7	4.5	9.4	4.9	—	Fast	No
Nan Mu 2010, a AD L	81	81	—	—	—	13	32	25.38	53.11	20.75	21.51	Serum	Fast	—
Nan Mu, 2010 b AD M	81	81	—	—	—	12	32	17.38	14.89	20.75	21.51	Serum	Fast	—
Nan Mu, 2010 c AD H	81	81	—	—	—	9	32	9.11	6.03	20.75	21.51	Serum	Fast	—
Yan-Wu, 2008 a VD L	62	62	—	—	—	35	15	12.89	4.52	10.01	4.15	—	Fast	—	H
Yan-Wu, 2008 b VD M	62	62	—	—	—	15	15	13.13	5.13	10.01	4.15	—	Fast	—	H
Yan-Wu, 2008 c VD H	62	62	—	—	—	11	15	15.32	5.31	10.01	4.15	—	Fast	—	H
Hong-li Li, 2013 AD	74	74	—	56	69	55	70	5.75	4.23	3.71	1.87	Serum	Fast	—	H

Note. Ex: experimental group; HC: healthy control group; HCs: healthy control subjects; Edu: average years of education of all participants; state: sampling time; drug: participants received or did not receive medication interventions during the course of the study; AD: Alzheimer’s disease; VD: vascular dementia; multi: nonpsychotic dementia caused by multiple diseases; MCI: mild cognitive impairment; L/M/H: different severities (light/mild, middle, and heavy) of nonpsychotic dementia, respectively; MVCI: mild cognitive impairment caused by vascular disease; H: high insulin levels in patients in the experimental group; L: low insulin levels in patients in the experimental group. This study included a comparison of log values, and although the value was <0.05, the actual analysis showed that insulin levels were not associated with events in nonpsychotic dementia.