Abnormal Resting-State Functional Connectivity Strength in Mild Cognitive Impairment and Its Conversion to Alzheimer’s Disease

Table 3

Clusters showing significant group effects on FCS.

Number	Brain regions	Brodmann area	Cluster size (mm^3)	Peak MNI coordinate			Max  score
				1	R ITG/FG/HIP/PHG	20/37/28		12,582	51	−27	−27	11.19
2	L FG/HIP	20/38	9,153	−30	−42	−24	10.78
3	R TPOmid	38	2,376	54	−6	−15	8.62
4	L ORBsup	11	7,668	−3	12	−18	11.71
5	B LING	18	6,183	−18	−60	−6	8.75
6	L MOG	19	1,701	−45	−72	6	8.30
7	B PCC/PCu/CUN	31/7/19	12,339	−3	−51	21	9.52
8	R ANG	39	1,863	39	−63	42	13.09
9	L ANG	39	2,241	−54	−57	36	7.49
10	L SFG	6	2,349	−18	9	60	10.83

Significance level: < 0.05; voxel size >1350 mm³; AlphaSim corrected < 0.05.
B, bilateral; L, left; R, right; ITG, inferior temporal gyrus; FG, frontal gyrus; HIP, hippocampus; PHG, parahippocampal gyrus; TPOmid, middle temporopolar; ORB sup, superior orbitofrontal cortex; LING, lingual gyri; MOG, middle occipital gyrus; PCC, posterior cingulate cortices; PCu, precuneus; ANG, angular gyri; SFG, superior frontal gyrus; CUN, cuneus.