Topological Properties of Large-Scale Cortical Networks Based on Multiple Morphological Features in Amnestic Mild Cognitive Impairment

Figure 1

Flowchart for the construction of structural cortical networks. (a) Two representative cortical thickness maps (left for a control subject and right for an aMCI subject) were obtained from anatomical MRI. The color bar indicating the range of thickness is shown on the right. (b) The cortical thickness was mapped into 148 regions and the partial correlation matrices were obtained between regional thicknesses across subjects within each group (left for NC and right for aMCI). The color bar indicating the partial correlation coefficient between regions is shown on the right. (c) The correlation matrices of (c) were thresholded into the binarized matrices (left for NC and right for aMCI) by sparsity of 5%. NC, normal controls.