A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back Pain

Figure 8

Comparison of the inhibitory potency of SANR (10 mM) on ectopic spontaneous discharge with the same concentration of Tempol and aspirin. (a) Frequency histogram showing the inhibition of ectopic spontaneous discharge of the injured DRG neurons by SANR, Tempol, and aspirin on the same cell. (b) Quantitative analysis showing that the inhibition rate by SANR () on spontaneous activity was much stronger than that by Tempol (, ) and aspirin (, ) alone. All data are expressed as mean ± S.E.M.

(a)

(b)