Evidence of Maintenance Tagging in the Hippocampus for the Persistence of Long-Lasting Memory Storage

Figure 1

(a) The promoting effect of OF is time-dependent. (A1, B1) Schematic representation of the experimental protocol is presented on the top of each panel. (A2) Animals were trained in the IA and exposed to an OF 5 h, 8 h, 11 h, or 24 h after a weak IA training. Test was performed 7 days after training. Only the exposure to an OF 11 h after training promotes the durability of IA memory. Data are presented as mean ± SEM. (b) Exploration of an open field 11 h after training promotes the persistence of weak IA memory. (B2) Animals were trained in the IA and exposed to an OF 11 h later. Test was performed in independent groups of animals at 1 day, 2 days, and 7 days after training. A retest was performed at 13 days only with the animals that had been tested at 7 days (note a small increase of latency in this control group probably due to the retest effect). Data are presented as mean ± SEM.

(a)

(b)