Chondroitin Sulfate Induces Depression of Synaptic Transmission and Modulation of Neuronal Plasticity in Rat Hippocampal Slices
Variation in the amplitude of synaptic evoked population spike responses following CS treatment. (a) The time-courses show average population spike (PS) amplitudes evoked orthodromically by stimulation of stratum radiatum that reveal that CS induces a drastic depression of their amplitude in a reversible manner. Bottom panels show representative PS taken at the times indicated by the letters A (control) and B (CS). (b) Time-courses of average PS amplitudes evoked antidromically by stimulation of stratum alveus and how CS was able to enhance their amplitude in a reversible manner. As indicated above, the original traces show representative population spike taken at the times indicated by the letters A (control) and B (CS). The graph plots data were normalized to the mean value of the 20 min control period and expressed as mean ± SEM/min ( slices).
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