Upregulation of EMMPRIN (OX47) in Rat Dorsal Root Ganglion Contributes to the Development of Mechanical Allodynia after Nerve Injury

Figure 6

DRG injection of OX47 shRNA markedly attenuated the development of mechanical allodynia. (a) OX47 mRNA expression in DRG of control RNA and OX47 shRNA group. Data show that OX47 shRNA obviously decreased the mRNA expression in the 7 d and 14 d after SNL. per group. , . (b) Increased paw withdrawal threshold after OX47 shRNA injection. Note that mechanical allodynia was remarkably attenuated in rats infected with lentivirus containing shRNA of OX47. per time point. compared to nonsilencing control shRNA (nonspecific scrambled shRNA).

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