Review Article
Immature Dentate Gyrus: An Endophenotype of Neuropsychiatric Disorders
Table 1
Behavioral, electrophysiological, and molecular phenotypes in mice with iDG.
| | | -CaMKII HKO [1] | Shn-2 KO [2] | SNAP-25 KI [3] | CN KO [4, 10, 21] | FLX treatment [5] | Pilocarpine treatment [6] |
| Behavioral phenotypes | Locomotor activity | | | | | [29] | | Working memory | [1–12] | | | | | [6, 30] | Social interaction | Mutants kill cagemates | | | | | | PPI | — | | | | — | |
| Electrophysiological phenotypes | Mossy fibre-CA3 synapse | | | | | | | Basal transmission | | | — | | — | | Frequency facilitation | | | | | | — | Granule cell soma | | | | | | | Passive | | | | | | | Input resistance | | | — | | — | — | Active | | | | | | | Excitability | | | | | | | Spike number | | | | | | |
| Molecular phenotypes | Markers of immature granule cells | | | | | | | Dopamine D1 receptor (Drd1a) | | — | | | [31] | | Calretinin | | | | | | | Markers of mature granule cells | | | | | | | Tryptophan 2,3-dioxygenase (Tdo2) | | | | | | | Desmoplakin (Dsp) | | | | | | | Calbindin | | | | | | | GluR1 | [32] | | | | — | | Immediate early genes induction | | | | | | | c-Fos or Arc-dVenus | [1, 13] | | | | | | Inflammation-related molecules | | | | | | | Glial fibrillary acidic protein (GFAP) | — | | | | [31] | [33] | Complement components | — | | | | [31] | [34] | MHC genes | — | | | | [31] | [34] | Adult neurogenesis | | | | | | | BrdU incorporation | | | | | [25] | [33, 35] |
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↑: Increased or upregulated. ↓: Decreased or downregulated. —: Nonsignificant.
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