|
| Gene target | Function | Cell/tissue type studied | Direct association with MeCP2 (cell line used for ChIP) | Reference |
|
| PCDHB1 | Cell adhesion | Oral cancer cell lines (ZA, KOSC2, HSC5, NA) | Yes (SH-SY5Y) | |
| PCDH7 | Cell adhesion | Yes (SH-SY5Y) | [68] |
| APBP3 | Intracellular signal transduction | Yes (SH-SY5Y) | |
|
| CLU | Extracellular molecular chaperone | | No (SH-SY5Y) | |
| CRMP1 | Component of semaphoring signal transduction pathway | | Yes (SH-SY5Y) | |
| DNMI | Vesicular trafficking, production of microtubule bundles, hydrolyzes GTP | | Yes (SH-SY5Y) | [69] |
| GNBI | Integrates signals between receptor and effector proteins | RTT patient brain (frontal cortex) | Yes (SH-SY5Y) | |
| APLP1 | Enhancer of neuronal apoptosis | | No (SH-SY5Y) | |
| CO1 | Mitochondrial respiratory chain | | No (SH-SY5Y) | |
| GDI1 | Regulates GDP/GTP exchange | | No (SH-SY5Y) | |
|
| Bdnf | Neuronal plasticity and survival | Mouse E14 cortical culture Rat E18 cortical neurons | Yes (mouse E14 cortical culture Rat E18 cortical Neurons) | [70, 71] |
|
| Fxyd1 | Ion transport regulator for Na, K-ATPase | RTT mice cerebellum RTT patient’s brain—superior frontal gyrus | Yes (adult mice brain, Mecp2 wt and Mecp2 null mouse; HEK293T cells) | [72, 73] |
|
Reln
Gtl2 | Neuronal layer formation, cell-cell interactions
Growth suppressor | RTT mice cerebellum | Yes (adult mice brain) |
[72] |
|
ID1
ID2
ID3
ID4 | Regulation of neuronal differentiation | SH-SY5Y | Yes (SH-SY5Y) | [74] |
|
| IGFBP3 | Modulation of IGF functions | RTT mice model | Yes (HeLa cells; mice cortices) | [75] |
|
UBE3A
GABRB3 | Ubiquitin ligase
GABA-A receptor | Brain cerebral samples of RTT, AS, and autism patients | No (adult mouse cerebellum samples) |
[76] |
|
Sst
Oprk1
Gamt
Gprin1
Mef2c
A2bp1 | Regulation of cell migration
Signal transduction
Organ morphogenesis
Neurite development
Neuron development and differentiation
RNA splicing and mRNA processing | RTT mice models (Mecp2 null and Mecp2 Tg) and control mice; Hypothalamus | Yes (RTT mice models (Mecp2 null and Mecp2 Tg) and control mice; Hypothalamus) | [23] |
|
| xHairy2a | Neuronal differentiation | Xenopus embryos | Yes (xenopus neurula stage embryos) |
[77] |
|
Sgk1
Fkbp5 | Cellular stress response
Hormone signalling | RTT mice model; brain samples | Yes (mice brain tissue) | [78] |
|
| Uqcrc1 | Mitochondrial respiratory chain | RTT mice model; brain samples | Yes (adult mice; whole brain) | [79] |
|
| Crh | Stress response | RTT mice model; brain samples | Yes (RTT mice brain samples) | [80] |
|
| Dlx5 | Transcription factor | Not done | Yes (mouse brain) | [81] |
|
