SCRAPPER Regulates the Thresholds of Long-Term Potentiation/Depression, the Bidirectional Synaptic Plasticity in Hippocampal CA3-CA1 Synapses
Figure 2
Long-term potentiation/depression (LTP/LTD) induction by stimulation at different frequencies in wild-type (WT) or Scrapper-knockout (SCR-KO) hippocampal slices. Left column: records of representative experiments in which LTP/LTD was induced. Low-frequency stimulation (LFS, 1 Hz, 900 s) (a), middle-frequency stimulation (MFS, 10 Hz, 90 s) (b), or high-frequency stimulation (HFS, 100 Hz, 1 s) (c) was used as the input. Right column: normalized means (± standard error of the mean (SEM)) of field excitatory postsynaptic potential (fEPSP) slopes from WT or SCR-KO hippocampal slices. Each point represents a single measure of the initial slope of the population excitatory postsynaptic potentials (EPSPs) evoked by stimulation of the Schaffer collaterals at 1/60 Hz. The horizontal bar or the arrow represents the period of stimulation. The number of mice, , and 4 in (a), (b), and (c), respectively. (◊, WT; ◆, SCR-KO).
