Deafferentation-Induced Redistribution of MMP-2, but Not of MMP-9, Depends on the Emergence of GAP-43 Positive Axons in the Adult Rat Cochlear Nucleus
Figure 3
Nissl staining used to document effectiveness and extent of KA injection into VNTB. (a, b) In the superior olivary complex of normal adult rats (a), numerous large neurons (arrows in (b)) were visible in VNTB (outlined in (a), (c), and (e)). Frames seen in (a), (c), and (e) indicate fields shown at high magnification in (b), (d), and (f). Dorsal (d) and medial (m) indicate orientation of brain sections. LSO: lateral superior olive; MNTB: medial nucleus of trapezoid body. (c), (d): VNTB with complete lesion (cL). All neurons have disappeared while glial cells (arrowheads in (d)) increased in number. (e, f) After incomplete VNTB lesions, neurons (arrows in (e) and (f)) survived in parts of VNTB (f). In the case shown in (e), medially residing neurons survived the injection (arrows) while most of the laterally residing neurons disappeared. Scale bar: 50 μm for (a), (c), and (e); 20 μm for (d), (d), and (f).
