Effect of N-Acetyl Cysteine on Intracerebroventricular Colchicine Induced Cognitive Deficits, Beta Amyloid Pathology, and Glial Cells

Figure 6

Quantitative estimation of number of GFAP positive astrocytes in various regions of the hippocampus. In CA1, CA2, CA3, and CA4 regions 350 μm length and in dentate gyrus (DG) 150μ2 area were selected for quantification. Note that, in all regions, the number of astrocytes was significantly increased in AD and AD+ NAC 50, AD+NAC 100 groups compared to control group. In dentate gyrus, number of astrocytes in AD+NAC-100 significantly decreased compared to AD group. Values are expressed as mean ±SE. Control/sham versus AD: ∗∗∗, p<0.001; control/sham versus AD+NAC50; or control/sham versus AD+NAC100: $$$, p<0.001, AD versus AD+NAC 100: #, p< 0.05 (one-way ANOVA, Bonferroni’s multiple comparison test, and n=6 in all groups).