Decision-Making in Multiple Sclerosis Patients: A Systematic Review

Table 2

Studies comparing decision-making in MS patients and HCs and baseline data of their respective cohorts.

Cohort	MS/CIS	HC	EDSS	MS-type	Disease duration; (mean (SD))	Age in years; (mean (SD))	Affective changes	Cognitive changes	Behavioural changes	Fatigue in MS patients
Farez et al. 2014 [18]	27	27	Mean: 1.03 (SD 0.8)	RR	7.9 months (8.1)	33.3 (9.7)	−	+	Nm	Nm
Simioni et al. 2012 [26]	72	38	Mean: 1.9 (SD: 0.5, range: 1.5–3)	RR	5.06 years (3.3)	34.6 (6.3)	+	+	−	Nm
Muhlert et al. 2014 [21]	105	43	Median: 5 (range: 0–8.5)	RR , SP , PP	14.9 years (9.6)	45.9 (10.4)	+	+	Nm	Nm
Radomski et al. 2015 [23]	32	20	Median: 3 (range: 0–6.5)	RR , SP	15.9 years (10.3)	50.8 (9.5)	−	+	+	+
Kleeberg et al. 2004 [20]	20	16	Median: 2 (range: 1.5–6.5)	RR , SP	Median 103 months (range: 7–300)	Median 38 (25–57)	+	+	+	Nm
Cogo et al. 2014 [17]	60	35	Mean 1.4 (SD: 1, range: 0–3.5)	RR	40.8 months (SD 45, range: 2–264)	34 (7.7)			nm	Nm
Simioni 2008 et al. [24]	109/56	50	MS: Mean 1.82 (SD: 0.4)	RR ,	2.8 (1.9) years	34 (9.3)	+	+	+	+
			CIS: Mean: 1.66 (SD: 0.4)	CIS	1.4 (1.3) years	37.9 (8.3)	+	+	+	+
García-Molina et al. 2008 [19]	18	18	Mean: 6.7 (SD: 0.69)	RR ; SP ; PP	17.14 (6.55) years	49.33 (7.8)	Nm	Nm	Nm	Nm
Nagy et al. 2006 [22]	21	30	Mean: 1.7 (range: 0–3)	RR	3.1 years (1.1)	32.4 (9.8)	Nm	+	Nm	Nm
Roca et al. 2008 [27]	12	12	<2	RR	Mean 29.5 months (SD 12.4, range: 11–36)	32.5 (7.97)	+	+	Nm	Nm
García-Molina et al. 2009 [16]	9	18	Mean: 7.2 (SD: 0.3)	PP	17.3 years (6.1)	51.4 (4.7)	Nm	Nm	Nm	Nm
	10	18	Mean: 7 (SD: 0.5)	SP	16.6 years (4.8)	46 (14.1)	Nm	Nm	Nm	Nm
Azcárraga-Guirola et al. 2016 [28]	16	19	Range: 2.5–4.5	RR ; SP ; not defined	8.9 years (7)	39.4 (12.6)	−	+	Nm	Nm

Nm: not measured; +: present; −: absent; HC: healthy controls; RR: relapsing remitting; SP: secondary progressive; PP: primary progressive; SD: standard deviation.