Increased Frequency of Pfdhps A581G Mutation in Plasmodium falciparum Isolates from Gabonese HIV-Infected Individuals

Table 1

Distribution of multiple Pfdhfr/Pfdhps mutation according to cotrimoxazole prophylaxis.

Multiple mutation^§	All	On CTX∗	Not on CTX
	(N=34)	(N=8)	(N=26)
Double mutation, n(%)	3(8.8)	2(25.0)	1(3.8)
S108N/I164U^+	1(2.9)	1(12.5)	0 (0.0)
S108/A437G	2(5.8)	1(12.5)	1(3.8)
Triple mutation,n()	12(35.3)	2(25.0)	10(38.5)
S108N/N51I/C59R	10 (29.4)	2(25.0)	8(30.8)
Triple pfdhfr-pfdhps
S108N/I164L/A581G	1(2.9)	0(0.0)	1(3.8)
S108N/A437G/A581G	1(2.9)	0(0.0)	1(3.8)
Quadruple mutation,n()	6(17.6)	2(25.0)	4(15.4)
Quadruple pfdhfr/pfdhps
S108N/N51I/C59R/A437G	2 (5.8)	1(1.25)	1(3.8)
S108N/N51I/C59R/A581G	3 (8.8)	0(0.0)	3(11.5)
S108N/N51I/A437G/A581G	1(2.9)	1(12.5)	0(0.0)
S108N/N51I/C59R/A437G
Quintuple mutation	3(8.8)	0(0.0)	3(11.5)
S108N/N51I/C59R/A437G/A581G	2 (5.9)	0	2(7.7)
S108N/N51I/C59R/I164U^+/A437G	1(2.9)	0	1(3.8)

carrying mutations at two or more codons. ⁺Unknown mutant genotype. ∗Two isolates carried SNP at codon S108N.