Association between Inflammatory Cytokine Levels and Thrombocytopenia during Plasmodium falciparum and P. vivax Infections in South-Western Coastal Region of India
Table 4
Cytokines during varying thrombocytopenia levels during patients with P. vivax, P. falciparum, and mixed infections.
Cytokines
P. vivax
NT
MT
MDT
ST
n (%)
75 (19.5%)
127 (33.1%)
129 (33.6%)
53 (13.8%)
Platelets x103/μl
183 (162-203)
124 (112-134)
79 (67-90)
30(22-40)
TNF-α (pg/ml)
131.7 (70.6-220.7)
208.0 (108.1-312.0)
213.0 (106.0-362.8)
431.9 (232.4-607.6)
IL-6 (pg/ml)
208.3 (109.0-366.6)
264.0 (154.3-402.4)
173.7 (111.8-249.8)
111.2 (79.9-158.5)
IL-10 (pg/ml)
373.9 (256.1-493.4)
502.1 (352.7-671.4)
641.8 (441.6-892.3)
892.8 (545.5-1556.0)
Cytokines
P. falciparum
n (%)
36 (20.9%)
48 (27.9%)
57 (33.1%)
31 (18.0%)
Platelets x 103/μl
166 (159-191)
127 (116-135)
80 (68-92)
29 (13-38)
TNF-α (pg/ml)
82.0 (51.0-127.2)
151.8 (56.2-249.5)
193 (78.2-312.5)
602.2 (359.4-761.6)
IL-6 (pg/ml)
247.0 (136.0-370.7)
324.1 (160.2-424.4)
284 (151.8-456.1)
140.4 (116.6-165.6)
IL-10 (pg/ml)
429.7 (169.7-701.5)
486.4 (267.0-751.0)
679.8 (372.2-978.9)
874.9 (348.5-1585.5)
Cytokines
Mixed
n (%)
23 (32.4%)
13 (18.3%)
19 (26.8%)
16 (22.5%)
Platelets x 103/μl
162 (154-182)
118 (118-136)
76 (56-84)
29 (20-36)
TNF-α (pg/ml)
83.8 (67.0-160.4)
154.2 (135.3-371.6)
189.1 (107.6-339.0)
284.9 (185.7-473.3)
IL-6 (pg/ml)
237.0 (93.1-308.5)
325.1 (227.3-403.9)
270.5 (153.5-417.7)
241.6 (115.6-380.7)
IL-10 (pg/ml)
506.4 (298.7-729.6)
531.3 (263.7-639.4)
722.1 (509.6-813.5)
883.6 (591.5-1064.1)
Data shown as median (inter quartile range 25% and 75%) and were analyzed by one-way nonparametric Kruskal-Wallis test for multiple comparisons and Mann Whitney U test for comparison between two groups.
