Role of Different Pfcrt and Pfmdr-1 Mutations in Conferring Resistance to Antimalaria Drugs in Plasmodium falciparum

Table 6

List of chloroquine sensitive strains of Plasmodium falciparum along with their geographic distribution and both pfcrt and pfmdr-1 haplotypes.

Strain

Geographic distribution

Pfcrt haplotype

Pfmdr-1

72

74

75

76

97

123

144

148

152

160

163

194

198

205

220

271

275

277

326

333

350

356

371

86

184

1034

1042

1246

D7 (wild type)

Southeast Asia and Africa

C

M

N

K

H

H

A

L

T

L

S

I

E

T

A

Q

P

N

N

T

C

I

R

N

Y

S

N

D

HB3

Honduras

C

M

N

K

H

H

A

L

T

L

S

I

E

T

A

Q

P

N

N

T

C

I

R

N

Y

S

D

D

GC03

Genetic-cross studies of Dd2 and HB3

C

M

N

K

H

H

A

L

T

L

S

I

E

T

A

Q

P

N

N

T

C

I

R

N

Y

S

N

D

MP2475

Malaysia

C

M

N

K

H

H

A

L

L

I

E

T

A

N

N

T

I

N

Y

S

N

D

MP2533

Malaysia

C

M

N

K

H

H

A

L

L

I

E

T

A

N

N

T

I

N

F

S

N

D

N29.07

Africa (Nigeria)

C

M

N

K

H

H

A

L

L

I

E

T

A

N

N

T

I

N

F

S

N

D

N60 and N92

Africa (Nigeria)

C

M

N

K

H

H

A

L

L

I

E

T

A

N

N

T

I

N

Y

S

N

D

Th230.08

Africa (Senegal)

C

M

N

K

H

H

A

L

L

I

E

T

A

N

N

T

I

N

Y

S

N

D

Tg060.07

Africa (Senegal)

C

M

N

K

H

H

A

L

L

I

E

T

A

N

N

T

I

N

F

S

N

D

P09.04 and P19.04

Africa (Pikine/Senegal)

C

M

N

K

H

H

A

L

L

I

E

T

A

N

N

T

I

N

Y

S

N

D

P31.01 and P08.04

Africa (Pikine/Senegal)

C

M

N

K

H

H

A

L

L

I

E

T

A

N

N

T

I

N

F

S

N

D

P11.02

Africa (Pikine/Senegal)

C

M

N

K

H

H

A

L

L

I

E

T

A

N

S

T

I

N

F

S

N

D

P27.02

Africa (Pikine/Senegal)

C

M

N

K

H

H

A

L

L

I

E

T

A

N

N

T

I

Y

F

S

N

D

P60.02

Africa (Pikine/Senegal)

C

M

N

K

H

H

A

L

L

I

E

T

S

N

N

T

I

N

F

S

N

D

K1 AM

Positive selection of K1H with amantadine

C

I

E

T

H

H

A

L

T

L

R

I

E

T

S

E

P

N

S

T

C

V

I

K1 HF

Positive selection of K1H with HF

C

I

E

T

H

H

A

L

A

L

R

I

E

T

S

E

L

N

S

T

C

I

I

Pf164

Southeast Asia

C

I

E

T

H

H

A

L

T

L

R

I

E

T

S

E

P

N

S

T

C

I

I

106/I

Sudan (Awad-el-Kariem FM 1992)

C

L

E

K

H

H

A

L

T

L

S

I

E

T

S

E

P

N

S

T

C

I

I

D10

Papau New Guinea

C

M

N

K

H

H

A

L

T

L

S

I

E

T

A

Q

P

N

N

T

C

I

R

N

Y

S

N

D

D6

Sierra Leone

C

M

N

K

H

H

A

L

T

L

S

I

E

T

A

Q

P

N

N

T

C

I

R

Y

Y

S

N

D

NF54

C

M

N

K

H

A

L

L

I

E

T

N

T

N

Y

S

N

D

H209

French Guinea

S

M

N

T

H

H

A

L

T

L

S

I

E

T

S

Q

P

N

D

T

R

L

R