Time Course of the Changes in Novel Trioxane Antimalarial 99/411 Pharmacokinetics upon Antiepileptic Drugs Co-Administration in SD Rats

Table 1

99/411 pharmacokinetics, alone and upon coadministration with AEDs in SD rats [data expressed as mean ± SD ()].

PK parameters	99/411 alone		99/411 + GB		99/411 + CBZ		99/411 + PHT
	Male	Female	Male	Female	Male	Female	Male	Female
(ng/mL)
(h)			6.50 ± 0.50*	2.00 ± 1.11*	6.50 ± 0.50*
(ng·h/mL)				4560 ± 1396*
(h)			2.66 ± 0.65*	5.02 ± 1.09*			2.10 ± 0.30*
MRT (h)
RB^# (%)	—	—	93	184*	119	85*	121*	87

Values are statistically significantly different at 95% CI (); ^#relative bioavailability.