Comparison of Inflammatory Cytokine Levels in Hepatic and Jugular Veins of Patients with Cirrhosis

Table 3

Comparison of serum cytokine levels between patients with compensated and decompensated cirrhosis.

	Jugular veins						p-Values
	Compensated	IQR		Decompensated	IQR
IL-1β, pg/ml	15.3	15.3	19.7	15.3	15.3	48.5	0.39
IFN-α2, pg/ml	1.5	0.8	2.6	3.5	1.5	6.1	0.02
IFN-γ, pg/ml	3.0	2.5	7.1	12.9	3.1	21.6	0.02
TNF-α, pg/ml	2.7	1.0	7.8	13.3	2.9	32.5	<0.01
MCP-1, pg/ml	105.9	86.5	139.5	114.0	70.0	206.0	0.74
IL-6, pg/ml	6.7	3.4	8.6	22.5	11.6	45.5	<0.01
IL-8, pg/ml	34.9	32.8	52.7	78.0	41.9	260.8	0.01
IL-10, pg/ml	3.9	1.9	8.4	20.4	8.3	44.2	<0.01
IL-12p70, pg/ml	3.4	1.4	4.6	5.0	1.5	16.5	0.10
IL-17A, pg/ml	0.2	0.2	0.3	0.8	0.2	1.7	0.02
IL-18, pg/ml	254.4	212.5	563.5	388.2	272.3	767.9	0.04
IL-23, pg/ml	3.2	3.2	4.8	19.1	3.2	31.3	0.06
IL-33, pg/ml	15.5	9.0	32.8	61.5	12.3	172.5	0.02
	Hepatic veins
IL-1β, pg/ml	15.3	15.3	15.6	15.3	15.3	34.3	0.33
IFN-α2, pg/ml	1.3	0.7	3.3	3.9	1.3	6.9	0.06
IFN-γ, pg/ml	3.8	2.5	6.7	11.5	3.5	23.8	0.02
TNF-α, pg/ml	2.3	1.0	7.9	17.7	1.8	34.7	0.03
MCP-1, pg/ml	105.4	81.7	174.4	116.3	76.2	232.6	0.69
IL-6, pg/ml	4.3	2.3	7.6	20.7	11.7	45.5	<0.01
IL-8, pg/ml	37.5	32.8	63.2	114.2	38.0	293.8	0.02
IL-10, pg/ml	5.8	2.4	9.4	19.3	8.1	50.2	0.01
IL-12p70, pg/ml	3.4	1.4	5.2	4.4	1.5	19.4	0.33
IL-17A, pg/ml	0.2	0.2	0.5	0.5	0.2	1.9	0.06
IL-18, pg/ml	279.5	231.5	482.1	414.4	293.9	675.5	0.08
IL-23, pg/ml	3.2	3.2	5.6	18.2	3.2	50.9	0.04
IL-33, pg/ml	15.9	7.2	57.1	63.2	18.5	207.1	0.04

Note. Data are expressed as median with interquartile ranges (IQR). p-values were assessed by the Mann–Whitney U-Test. When significance between the groups was reached, values are printed in bold. IL, interleukin; IFN, interferon; MCP-1, monocyte chemotactic protein-1; TNF, tumor necrosis factor; CRP, C-reactive protein.