The Prognosis Role of AST/ALT (De Ritis) Ratio in Patients with Adult Secondary Hemophagocytic Lymphohistiocytosis
Table 3
Stratified associations between De Ritis ratio and overall survival.
Subgroups
1 st tertile
2 st tertile
3 st tertile
for trend
for interaction
OR (95% CI)
OR (95% CI)
OR (95% CI)
Gender
0.874
Male
1 (ref)
0.8 (0.5-1.3)
1.4 (0.9-2.1)
0.175
Female
1 (ref)
1.2 (0.6-2.5)
1.4 (0.7-2.8)
0.317
0.950
Yes
1 (ref)
1.1 (0.7-1.8)
1.4 (0.9-2.2)
0.203
No
1 (ref)
1.0 (0.5-2.0)
1.5 (0.8-2.7)
0.168
0.095
Yes
1 (ref)
1.0 (0.7-1.5)
1.3 (0.9-1.9)
0.157
No
1 (ref)
0.4 (0.07-2.6)
3.2 (0.6-16.9)
0.212
0.985
Yes
1 (ref)
1.2 (1.0-4.6)
2.1 (1.0-4.6)
0.035
No
1 (ref)
1.0 (0.7-1.6)
1.4 (0.9-2.1)
0.165
0.249
Yes
1 (ref)
0.8 (0.5-1.3)
1.1 (0.7-1.7)
0.470
No
1 (ref)
1.6 (0.8-3.3)
2.6 (1.3-5.2)
0.009
EBV infection
0.329
Yes
1 (ref)
1.1 (0.7-1.8)
1.1 (0.7-1.8)
0.634
No
1 (ref)
1.1 (0.6-2.0)
2.1 (1.2-3.6)
0.005
MHLH
0.209
Yes
1 (ref)
1.2 (0.7-1.9)
1.8 (1.1-2.8)
0.014
No
1 (ref)
0.8 (0.4-1.5)
1.1 (0.6-1.9)
0.496
Chemotherapy
0.748
Yes
1 (ref)
1.2 (0.8-1.8)
1.5 (1.1-2.2)
0.024
No
1 (ref)
0.04 (0.003-0.5)
1.4 (0.4-5.7)
0.188
Analyses were adjusted for hepatomegaly, albumin (ALB), fibrinogen (FIB), EBV, ferritin, malignancy-associated HLH (MHLH), and treatment strategies when they were not stratified variables.
