Research Article
The Prognosis Role of AST/ALT (De Ritis) Ratio in Patients with Adult Secondary Hemophagocytic Lymphohistiocytosis
Table 1
Baseline demographic, clinical, and laboratory characteristics of the study patients according to tertiles of AST/ALT (De-Ritis ratio).
| | 1 st tertile () | 2 st tertile () | 3 st tertile () | value |
| | De Ritis ratio | 0.68 (0.50-0.85) | 1.34 (1.17-1.58) | 2.89 (2.28-3.96) | <0.001 | | ALT, U/L | 90.9 (52.0-193.2) | 67.9 (37.3-147.9) | 46.2 (26.9-98.4) | <0.001 | | AST, U/L | 55.9 (32.2-125.9) | 96.4 (49.6-196.6) | 140.0 (81.40-288.0) | <0.001 | | Male, (%) | 58 (59.8) | 65 (68.4) | 56 (57.7) | 0.271 | | Age, years | 49 (37-64) | 55 (43-66) | 58 (42-65) | 0.074 | | ANC, 109/L | 1.13 (0.82-2.73) | 0.98 (0.69-1.92) | 0.89 (0.69-2.32) | 0.132 | | HB, g/L | 89 (74-103) | 85 (69-104) | 83 (70-94) | 0.277 | | PLT, 109/L | 61 (35-90) | 41 (24-61) | 36 (20-60) | <0.001 | | LDH, U/L | 452 (336-660) | 676 (382-1025) | 1195 (683-1990) | <0.001 | | ALB, g/L | 27.60 (5.01) | 27.02 (5.47) | 26.87 (4.59) | 0.568 | | TG, mmol/L | 2.36 (1.60-3.57) | 2.35 (1.63-3.27) | 2.86 (2.00-4.43) | 0.002 | | FIB, g/L | 1.66 (1.11-2.32) | 1.44 (0.91-2.12) | 1.46 (1.05-2.18) | 0.466 | | Ferritin, ug/L | 3137 (1321-8024) | 5043 (2193-14576) | 6258 (1600-17400) | 0.016 | | sCD25, ng/L | 31212 (17540-43915) | 34687 (16915-51866) | 37622 (17744-54064) | 0.607 | | Splenomegaly (%) | 85 (87.6) | 82 (86.3) | 89 (91.8) | 0.465 | | Hepatomegaly (%) | 15 (15.5) | 21 (22.1) | 16 (16.5) | 0.437 | | Lymphadenopathy (%) | 42 (43.3) | 56 (58.9) | 53 (54.6) | 0.08 | | Hemophagocytic (%) | 91 (93.8) | 86 (90.5) | 80 (82.5) | 0.035 | | HScore, points | 224 (196-258) | 239 (207-269) | 244 (220-274) | 0.011 | | EBV infection (%) | 45 (46.4) | 56 (58.9) | 45 (46.4) | 0.134 | | Etiology | | | | 0.053 | | MHLH (%) | 46 (47.4) | 57 (60.0) | 62 (63.9) | | | Non-MHLH (%) | 51 (52.6) | 38 (40.0) | 35 (36.1) | | | Chemotherapy (%) | 86 (88.7) | 88 (92.6) | 84 (86.6) | 0.39 |
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Abbreviations: ALT: alanine transaminase; AST: aspartate transaminase; De-Ritis ratio: aspartate transaminase/alanine transaminase; ANC: absolute neutrophil count; HB: hemoglobin; PLT: platelet; LDH: lactate dehydrogenase; ALB: albumin; TG: triglyceride; FIB: fibrinogen; sCD25: soluble interleukin-2 receptor; β2-MG: beta2-microglobulin; EBV: Epstein-Barr virus; MHLH: malignancy-associated hemophagocytic lymphohistiocytosis; Non-MHLH: nonmalignancy associated hemophagocytic lymphohistiocytosis.
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