NPY Receptor 2 Mediates NPY Antidepressant Effect in the mPFC of LPS Rat by Suppressing NLRP3 Signaling Pathway

<div>Time schedule for the experiment. LPS was injected for 4 days. Depressive-like behavior tests included OFT and SPT. NPY (1 nmol), Y2R agonist (PYY (3-36), 1 nmol), or Y2R antagonist (BIIE0246, 40 nmol) treatment were locally injected into the mPFC.</div>

Mediators of Inflammation

fig1

Figure 1

Figure 1: NPY Receptor 2 Mediates NPY Antidepressant Effect in the mPFC of LPS Rat by Suppressing NLRP3 Signaling Pathway 