Interleukin-7 Resensitizes Non-Small-Cell Lung Cancer to Cisplatin via Inhibition of ABCG2

Figure 4

Both IL-7R knockdown and PI3K activation suppressed IL-7-ehanced cell proliferation by DDP. After being pretreated with siRNA against IL-7Rα (si IL-7Rα), 740 Y-P (10 nM), or control, the A549/DDR cells were exposed to IL-7 (2 ng/mL) and DDP (0.5 μg/mL). At 24 h, 48 h, and 72 h after the combinational treatment, the cell viabilities were determined by CCK-8 assays (a). At 48 h after the combinational treatment, the proliferation was evaluated by colony formation assay (b, c) and by EdU staining (d, e). NC means cells were pretreated with negative control siRNA. and , as compared with the cells pretreated with the control. Data are presented in terms of .

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