|
| lncRNA | Disease | Expression of lncRNA in macrophage | Effects | Mechanism | Model | Ref. |
|
Gene | E330013P06 | Diabetes mellitus | Increased | Upregulation of IL-6, TNF-α, NOS2; downregulation of IL-10 | E330013P06 regulate expression of nearby genes involved in macrophage function. | Human Mice | [37] |
Protein | Lethe | Diabetes mellitus | Decreased | Production of ROS | Lethe binds to p65 subunit and inhibits the translocation of NF-κB to the nucleus. | Mice | [39] |
Protein | Dnm3os | Diabetes mellitus | Increased | Enhancement of inflammation and phagocytosis. Upregulation of IL-6, TNF, NOS2. | Dnm3os promotes proinflammatory function by both cis- and tran-action, and possibly via changes in epigenetic histone modifications. This is modulated by nucleolin. | Human Mice | [38] |
Unknown | MALAT1 | Diabetic atherosclerosis | Increased | Induction of pyroptosis | Unknown. | Rats | [40] |
ceRNA | NIFK-AS1 | Endometrial cancer | Decreased | NIFK-AS1 overexpression suppresses the IL-4-induced M2 polarization of macrophages and malignant behaviors of endometrial cancer. | NIFK-AS1 downregulates miR-146a. | Human | [46] |
ceRNA | CCAT1 | Prostate cancer | Increased in M1 | CCAT1 knockdown promoted M2 macrophage polarization. | CCAT1 targets miR-148a which regulates the expression of PKCζ. | Human Mice (in vitro) | [45] |
Gene | TUC339 | Hepatocellular carcinoma | Increased | TUC339 reduces IL-1β and TNF-α, decreases costimulatory molecule expression, and compromises phagocytosis. | Enriched TUC339 in PLC/PRF/5-derived exosomes is internalized by macrophage thus changes downstream pathways. | Human | [44] |
Gene | NEAT1 | Thyroid carcinoma | Increased | Knockdown of NEAT1 impairs the malignant progression of thyroid papillary carcinoma-1 and inhibits thyroid tumor growth in vivo. | NEAT1 decreases the expression of miR-214. | Human Mice | [58] |
Gene | LNMAT1 | Bladder cancer | Increased | LNMAT1 promotes invasiveness and lymphatic metastasis, and activates and recruits macrophages into the tumor, inducing lymph angiogenesis. | LNMAT1 recruits hnRNPL to CCL2 promoter leading to increased H3K4 trimethylation and CCL2 expression. | Human Mice | [43] |
Unknown | Cox2 | Hepatocellular carcinoma | Increased in M1 | Change of Cox2 alters M1/M2 polarization, regulating immune evasion and metastasis of HCC. | Unknown. | Mice | [47] |
ceRNA | MIAT | Atherosclerosis | Increased | Knockdown of MIAT attenuates atherosclerosis progression, promotes atherosclerotic plaque stability, and improves efferocytosis. | MIAT acts as ceRNA to positively regulate CD47 expression by sponging miR-149-5p. | Human Mice | [52] |
ceRNA | GSA5 | Atherosclerosis | Increased | Upregulation of IL-6, IL-1β, TNF-α, MCP-1, MMP-2, MMP-9. | GSA5 directly binds and suppresses miR-221 expression. | Human | [51] |
ceRNA | HOTAIR | Atherosclerosis | Increased | HOTAIR greatly increases total cholesterol, triglyceride levels, dil-ox-LDL uptake rate, ROS, IL-6, IL-1β, TNF-α, and Cox2 levels. | HOTAIR serves as a sponge of miR-330-5p. | Human | [50] |
ceRNA | UCA1 | Atherosclerosis | Increased | UCA1 increases ROS and cell apoptosis. | UCA1 sponges miR-206. | Human | [49] |
Gene | H19 | Atherosclerosis | Increased | H19 increases TG, TC LDL-C, IL-1β, TNF-α. | H19 upregulates the expression of miR-130b. | Human Mice (in vitro) | [59] |
Protein | MeXis | Atherosclerosis | Increased | Loss of MeXis impairs macrophage Abca1 expression and accelerates atherosclerosis. | MeXis interacts with and guides promoter binding of the transcriptional coactivator DDX17 to amplify gene Abca1. | Human Mice | [54] |
Protein | CDKN2B-AS1 | Atherosclerosis | Decreased | CDKN2B-AS1 inhibits inflammatory response and promotes cholesterol efflux. | CDKN2B-AS1 binds to DNA methyltransferase 1 to enhance methylation of ADAM10 promoter which inhibits AMAM10. | Human Mice | [53] |
Unknown | ENST00000444488.1 and Uc010yfd.1 | Coronary artery disease | Increased (ENST00000444488.1); decreased (Uc010yfd.1) | Silencing of ENST00000444488.1 and Uc010yfd.1 decreases or increases proinflammatory cytokines, respectively. | Unknown. | Human | [55] |
Unknown | NEAT1 | Myocardial infarction | Increased | Knockdown of NEAT1 disturbs monocyte-macrophage differentiation and its function. | Unknown. | Human Mice | [60] |
ceRNA | CHRF | Pulmonary fibrosis | Increased | CHRF promotes silica-induced pulmonary fibrosis and upregulates IL-1β, TGF-1β. | CHRF negatively regulates miR-489. | Human Mice | [61] |
ceRNA | KCNQ1OT1 | Osteolysis | Decreased in M1 | Overexpression of KCNQ1OT1 induces M2 polarization to ameliorate PMMA-induced osteolysis. | KCNQ1OT1 functions as a miR-21a-5p decoy which regulates IL-10 expression. | Mice | [62] |
Gene | HIF1A-AS1 | Liver failure | Increased | HIF1A-AS1 promotes TNF-α-induced apoptosis. | HIF1A-AS1 upregulates the expression of caspase. | Mice (in vitro) | [63] |
Protein | NTT | Rheumatoid arthritis | Increased | Rheumatoid arthritis lead to overexpression of PBOV-1 in macrophage, resulting in cell cycle arrest. | NTT regulates downstream gene PBOV-1 via HnRNP-U binding and is regulated by C/EBPβ. | Human | [56] |
Unknown | H19 | Rheumatoid arthritis; osteoarthritis | Increased | Unknown. | Unknown. | Human | [64] |
Unknown | HOTAIR | Rheumatoid arthritis | Increased | HOTAIR induces the migration of active macrophage. | Unknown. | Human | [65] |
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