Concomitant Treatment with Etanercept and Tacrolimus Synergistically Attenuates Arthritis Progression via Inhibition of Matrix Metalloproteinase-3 Production and Osteoclastogenesis in Human TNF-<i>α</i> Transgenic Mice

<div>Concomitant treatment with etanercept and tacrolimus attenuates the joint damage in hTNF-Tg mice. Representative H&amp;E-stained sections of the carpal joints from hTNF-Tg mice following treatment with (a) vehicle, (b) etanercept, (c) tacrolimus, and (d) etanercept plus tacrolimus are shown. Arrows, arrowheads, and asterisks in H&amp;E-stained sections indicate infiltration of inflammatory cells, bone destruction, and synovial hyperplasia, respectively.</div>

Mediators of Inflammation

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Figure 2: Concomitant Treatment with Etanercept and Tacrolimus Synergistically Attenuates Arthritis Progression via Inhibition of Matrix Metalloproteinase-3 Production and Osteoclastogenesis in Human TNF-<i>α</i> Transgenic Mice 

Figure 2 | Concomitant Treatment with Etanercept and Tacrolimus Synergistically Attenuates Arthritis Progression via Inhibition of Matrix Metalloproteinase-3 Production and Osteoclastogenesis in Human TNF-α Transgenic Mice 