Irisin Attenuates Neuroinflammation and Prevents the Memory and Cognitive Deterioration in Streptozotocin-Induced Diabetic Mice

Figure 6

Irisin reduced the activation of p38, STAT3, and NFκB proteins in the brain hippocampal tissues of DM mice. (a) Representative western blot photograph and statistical results of p-p38 and total p38 in hippocampal tissues of all groups. (b) Representative western blot photograph and statistical results of p-STAT3 and total STAT3 in hippocampal tissues of all groups. (c) NFκB/DNA binding activity was determined by EMSA. All data are expressed as . . vs. Cont; vs. STZ.

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