Anti-Inflammatory Effect of Columbianetin on Lipopolysaccharide-Stimulated Human Peripheral Blood Mononuclear Cells

Table 1

Nineteen significantly downregulated genes in the CBT-treated groups (fold change > 1.5) by CBT.

Number	Gene name	M/N	D/M	Description
1	BCL2L1	2.10	1.74	BCL2-like 1
2	BIRC3	2.03	1.96	Baculoviral IAP repeat containing 3
3	CASP5	2.8	2.54	Caspase 5, apoptosis-related cysteine peptidase
4	CXCL1	3.28	2.02	Chemokine (C-X-C motif) ligand 1
5	CXCL2	2.7	1.88	Chemokine (C-X-C motif) ligand 2
6	HSP90AA1	2.08	2.26	Heat shock protein 90 kDa alpha, class A member 1
7	IL-1β	2.82	1.51	Interleukin 1, beta
8	IRF2	1.97	2.07	Interferon regulatory factor 2
9	MAPK12	1.68	3.03	Mitogen-activated protein kinase 12
10	MEFV	1.65	1.85	Mediterranean fever
11	NFKB1	2.1	1.74	Nuclear factor of kappa light polypeptide gene enhancer in B-cell 1
13	NLRC5	1.74	2.96	NLR family, CARD domain containing 5
13	NLRX1	3.51	1.57	NLR family, CARD domain containing 5
14	NOD1	1.76	2.29	Nucleotide-binding oligomerization domain containing 1
15	P2RX7	3.16	1.61	Purinergic receptor P2X, ligand-gated ion channel, 7
16	PANX1	2.20	1.74	Pannexin 1
17	PTGS2	7.1	1.56	Prostaglandin-endoperoxide synthase 2
18	TNF	2.47	2.44	Tumor necrosis factor
19	TNFSF11	2.51	2.01	Tumor necrosis factor (ligand) superfamily, member 11