Lepidium meyenii Walp Exhibits Anti-Inflammatory Activity against ConA-Induced Acute Hepatitis

Figure 6

Inhibitory effects of Maca on liver damage and apoptosis-related protein expression in ConA-induced acute hepatitis. Liver tissues were collected from mice 16 hours after ConA challenge and analyzed by Western blot. (a) Effects of Maca on P-P65, P65, P-IκB-α, IκB-α, P-STAT1, STAT1, P-STAT3, and STAT3 expression were confirmed by Western blot. (b–i) Quantification of relative protein expression was performed by densitometric analysis. GAPDH was used as internal control. The similar results are representative of three experiments. Data is expressed as the mean ± SD (). , , and vs. the ConA group. ConA, concanavalin A; Maca, Lepidium meyenii Walp; P-P65, phosphorylated P65; P-IκB-α, phosphorylated nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha; IκB-α, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha; P-STAT1, phosphorylated signal transducer and activator of transcription 1; STAT1, signal transducer and activator of transcription 1; P-STAT3, phosphorylated signal transducer and activator of transcription 3; STAT3, signal transducer and activator of transcription 3.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)