Role of Epidermal Growth Factor Receptor (EGFR) and Its Ligands in Kidney Inflammation and Damage

Figure 1

Types of signaling via epidermal growth factor receptor (EGFR) ligands: (A) the autocrine form if EGFR activation occurs in the same cell; (B) the juxtacrine form, when the ligand is anchored to the cell membrane; (C) the extracrine form, which combines features of autocrine, paracrine, and juxtacrine signaling as well as possibly endocrine signaling; and (D) the paracrine form if acting in a neighbouring cell. Adapted from Singh et al. 2016.