Icaritin Provokes Serum Thrombopoietin and Downregulates Thrombopoietin/MPL of the Bone Marrow in a Mouse Model of Immune Thrombocytopenia
Table 1
Blood routine of all groups.
Group
Control
Model
rhTPO
Y003-L
Y003-M
Y003-H
PLT
465.0 ± 23.2
293.9 ± 61.7###
645.1 ± 106.7
555.2 ± 45.1
536.8 ± 49.1
568.8 ± 94.3
PCT
0.166 ± 0.009
0.126 ± 0.020###
0.191 ± 0.064
0.226 ± 0.022
0.231 ± 0.021
0.254 ± 0.047
PDW
13.85 ± 0.40
13.78 ± 1.05
14.15 ± 0.54
13.88 ± 0.47
13.84 ± 0.15
14.11 ± 0.55
MPV
3.73 ± 0.07
4.56 ± 0.34###
4.30 ± 0.25
4.19 ± 0.15
4.38 ± 0.16
4.56 ± 0.17
WBC
5.79 ± 1.95
7.5 ± 1.19
8.16 ± 1.61
8.61 ± 2.41
7.25 ± 1.36
6.18 ± 1.93
RBC
8.98 ± 0.52
8.74 ± 0.38
8.57 ± 0.53
8.84 ± 0.27
8.52 ± 0.61
8.65 ± 0.53
HGB
141.0 ± 9.62
137.9 ± 5.77
133.3 ± 7.30
138.2 ± 4.23
135.0 ± 10.24
134.5 ± 8.18
HCT
39.59 ± 2.22
40.23 ± 1.91
39.26 ± 2.20
40.06 ± 1.44
38.75 ± 2.88
39.25 ± 2.45
MCV
44.11 ± 0.50
46.00 ± 0.81###
45.88 ± 0.67
45.34 ± 1.03
45.48 ± 0.55
45.36 ± 0.44
MCH
15.70 ± 0.32
15.77 ± 0.31
15.56 ± 0.21
15.67 ± 0.45
15.85 ± 0.24
15.53 ± 0.23
MCHC
356.1 ± 7.0
342.8 ± 7.4##
339.5 ± 6.0
345.4 ± 13.3
348.4 ± 8.8
342.6 ± 5.8
RDW
12.94 ± 0.35
14.32 ± 1.90
13.45 ± 0.41
13.68 ± 0.25
13.51 ± 0.30
13.52 ± 0.21
LYM
3.24 ± 1.81
3.54 ± 0.56
3.50 ± 1.24
4.40 ± 1.54
3.93 ± 0.84
2.75 ± 1.50
MID
0.66 ± 0.31
1.89 ± 0.68##
2.27 ± 0.49
2.39 ± 1.38
1.91 ± 0.36
2.39 ± 0.55
PLT: platelets; PCT: plateletcrit; PDW: platelet distribution width; MPV: mean platelet volume; WBC: white blood cell; RBC: red blood cell; HGB: hemoglobin; HCT: hematocrit; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; RDW: red cell distribution width; LYM: lymphocyte; MID: intermediate cell; GRN: granulocytes. The data are presented as the mean ± SD ( per group). and versus control group; and versus model group.
