Comparative Expression Analyses of Pro- versus Anti-Inflammatory Mediators within Synovium of Patients with Joint Trauma, Osteoarthritis, and Rheumatoid Arthritis

Figure 1

Detection of 5-LOX mRNA (a) and number of 5-LOX-IR cells (b and c) in patients with joint trauma (JT), osteoarthritis (OA), and rheumatoid arthritis (RA). (a) Quantification of 5-LOX mRNA using TaqMan qRT-PCR shows that 5-LOX mRNA was significantly higher in RA compared to JT, OA, and control synovium (, one-way ANOVA followed by Tukey’s test). (b) Quantitative analysis of immunofluorescence microscopy for 5-LOX-IR cells. ^∗Relative to control, ^#relative to other groups (, one-way ANOVA followed by Tukey’s test). (c) 5-LOX-IR cells are more abundant in RA synovium than in JT, OA, and control synovium. Bar  =  20 μm.

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