Skin Immune Landscape: Inside and Outside the Organism

Table 2

Major constituents of the adaptive immunity.

Compartments	Cells	Inflammatory mediators
Dermis	DCs	MHC, CD80/CD86, IFN-β
	CTL	Enzymes, caspases
	TH1	IFN-γ, IL-2, TNF-α, IL-12
	TH2	IL-4, IL-5, IL-13 IL-4, IL-6, IL-15
	TH17	IL-17, IL-22
	TH 22	IL-22
	B cells	IgA, IgE, IgG, IgD, IgM

DCs: dendritic cells; CTL: cytotoxic T lymphocytes; TH: T helper; MHC: major histocompatibility class; IFN: interferon; CD: cluster of differentiation; IL: interleukin; TNF: tumor necrosis factor; Ig: immunoglobulin.