Skin Immune Landscape: Inside and Outside the Organism

Table 1

Major constituents of the innate immunity.

Compartments	Cells	Inflammatory mediators
Epidermis	KC	AMPs, IL-1β, IL-8, IL-10
	LC	IL-1, TNF-α, IL-10, IL-15
Dermis	Fibroblasts	IL-6, TNF-α, IL-8, IL-1, MMP-9, MMP-2
	MØ	ROS, NO, L-1, IL-6, IL-8, IL-12, IL-10, TNF-α, TGF-β
	NKs	IL-4, IL-10

KC: keratinocyte; LC: Langerhans cell; MØ: macrophage; NK: natural killer; AMPs: antimicrobial peptides; IL: interleukin, TGF: tumor growth factor; TNF: tumor necrosis factor; MMP: matrix metalloproteinases; ROS: reactive oxygen species; NO: nitric oxide.