Cannabinoid Receptor 2 Modulates Neutrophil Recruitment in a Murine Model of Endotoxemia

Figure 7

Proposed model for CB₂ function in endotoxemia. During acute systemic inflammation CB₂ suppresses neutrophil recruitment to the spleen. In the absence of this GPCR, the serum levels of the metalloproteinase MMP-9 are elevated and Ccl2, Ccl3, Cxcl10, and Il6 in the spleen are upregulated. As a result CB₂ knockout, neutrophils follow the chemokine gradient and migrate to the spleen in higher numbers than in control littermate animals.