Mediators of Inflammation

Research Article

Gene Expression, Oxidative Stress, and Senescence of Primary Coronary Endothelial Cells Exposed to Postprandial Serum of Healthy Adult and Elderly Volunteers after Oven-Cooked Meat Meals

Table 2

Representative genes with greatest fold differences in HCAEC exposed to fasting or postprandial serum from adult and elderly donors.


Probeset ID	Gene symbol	Gene name	Fold-change postprandial versus fasting adult serum	value	Fold-change postprandial versus fasting elderly serum	value

(a) Upregulated genes
205749_at	CYP1A1	Cytochrome P450, family 1, subfamily A	3.7992	<0.0001	2.4956	0.0008
228770_at	GPR146	G protein-coupled receptor 146	2.0300	0.0003	1.8857	0.0361
227652_at	FAM69B	Family with sequence similarity 69, member B	1.5366	0.0264	1.9603	0.0330
221565_s_at	CALHM2	Calcium homeostasis modulator 2	1.4354	0.0143	2.3629	0.0006
209830_s_at	SLC9A3R2	Solute carrier family 9, subfamily A	1.3971	0.0364	3.4436	<0.0001
219020_at	HS1BP3	HCLS1 binding protein 3	1.3794	0.0026	1.5682	0.0089
226488_at	RCCD1	RCC1 domain containing 1	1.3371	0.0127	1.7111	0.0054
211143_x_at	NR4A1	Nuclear receptor subfamily 4, group A, member 1	1.2800	0.0264	1.5553	0.0159
223415_at	RPP25	Ribonuclease P/MRP 25 kDa subunit	1.2674	0.0352	1.8069	0.0020
207978_s_at	NR4A3	Nuclear receptor subfamily 4, group A, member 3	1.2430	0.0310	1.4449	0.0261
(b) Downregulated genes
210631_at	NF1	Neurofibromin 1	−1.6760	0.0017	−1.8129	0.0228
1569867_at	EME2	Essential meiotic structure-specific endonuclease	−1.4108	0.0338	−1.7198	0.0406
225160_x_at	MDM2	MDM2 protooncogene, E3 ubiquitin protein ligase	−1.4035	0.0112	−1.5440	0.0435
1553113_s_at	CDK8	Cyclin-dependent kinase 8	−1.3286	0.0020	−1.6654	0.0008
224712_x_at	SMIM7	Small integral membrane protein 7	−1.3229	<0.0001	−1.3019	0.0067
1552487_a_at	BNC1	Basonuclin 1	−1.3185	0.0470	−1.6384	0.0311
226881_at	GRPEL2	GrpE-like 2, mitochondrial (E. coli)	−1.3133	0.0129	−1.4588	0.0332
229027_at	PPM1A	Protein phosphatase, Mg2+/Mn2+ dependent, 1A	−1.3019	0.0236	−1.5777	0.0173
228397_at	TUG1	Taurine upregulated 1 (nonprotein coding)	−1.2723	0.0400	−1.5252	0.0285
221203_s_at	YEATS2	YEATS domain containing 2	−1.2717	<0.0001	−1.3036	0.0024

The present analysis is restricted to the top 10 upregulated and downregulated genes expressed in HCAEC treated with postprandial sera withdrawn after pork meat meals versus fasting serum.