Research Article

SP600125 Attenuates Nicotine-Related Aortic Aneurysm Formation by Inhibiting Matrix Metalloproteinase Production and CC Chemokine-Mediated Macrophage Migration

Figure 2

SP600125 attenuates the formation of aortic aneurysm induced by nicotine plus AngII. (a) Representative photomicrographs of abdomens of mice of all four experimental groups. No aortic aneurysms were detected in saline-, nicotine-, or AngII-treated groups. Nicotine plus AngII induced the formation of aortic aneurysms (published in Experimental & Clinical Cardiology [14]). (b) Representative photomicrographs of abdomens of the mice in the cotreatment and SP600125-supplemented groups. Nicotine plus AngII induced the formation of aortic aneurysms. No aortic aneurysms were detected in the SP600125 group. (c, d) In all experimental groups, the body weight did not change from initiation to the end of the experiment. (e, f) The maximum diameter of the suprarenal abdominal aorta was measured using ImageJ and normalized to the body surface area, which was calculated using the Meeh–Rubner formula (area = , : weight, ). Data are represented as the mean ± SEM. versus nicotine or AngII group; refers to versus control group. AAA, abdominal aortic aneurysm.
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