Review Article
Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation
Table 3
Inflammatory effects on endocannabinoid system.
| Cell or tissue | Stimulus in vitro or animal model | Effect | Reference |
| Macrophages | Thioglycollate in vivo | ↑ CB2 receptor | Carlisle et al. [128] |
| Microglial cells | Interferon-γ | Induces CB2 receptor | Walter et al. [129] | | Maresz et al. [130] |
| Thioglycollate-elicited macrophages | LPS | ↓ CB2 receptor | Carlisle et al. [128] | | Cabral et al. [131] |
| Microglial cells | LPS in vivo | ↑ CB2 receptor | Mukhopadhyay et al. [132] | | Concannon et al. [133] |
| Blood mononuclear cells | LPS in vivo | ↓ fatty acid amide hydrolase activity | Wolfson et al. [134] |
| Spleen & liver | LPS in vivo | ↓ 2-arachidonyl glycerol hydrolytic activity | Szafran et al. [135] |
| Monocytes | LPS | ↑ anandamide | Varga et al. [136] |
| Macrophages | LPS | ↑ 2-arachidonyl glycerol | Pestonjamasp and Burstein [137] | ↓ 2-arachidonyl glycerol hydrolytic activity | |
| Dendritic cells | LPS | ↑ 2-arachidonyl glycerol | Matias et al. [138] |
| RAW 264.7 cells | LPS | Induces CB1 receptor | Walter et al. [129] | ↑ CB2 receptor | Mukhopadhyay et al. [132] | | Friedman et al. [139] | ↑ anandamide | Liu et al. [23] | ↑ N-acyltransferase | Pestonjamasp and Burstein [137] | ↑ phospholipase D | |
| J774 cells | LPS | ↑ anandamide | Di Marzo et al. [140] | ↑ 2-arachidonyl glycerol | Pestonjamasp and Burstein [137] | ↓ 2-arachidonyl glycerol hydrolytic activity | |
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