Research Article

CETP Lowers TLR4 Expression Which Attenuates the Inflammatory Response Induced by LPS and Polymicrobial Sepsis

Figure 8

CETP reduces the release of IL-6 levels in LPS-stimulated macrophages. Peritoneal macrophages from WT mice were stimulated for 24 h with LPS-Alexa Fluor 488 (1 µg/mL) in the absence or in the presence of different concentrations of recombinant human CETP (0.1, 0.5, and 1.0 µg/mL). IL-6 concentration release to cell culture medium decreased dose dependently in the presence of CETP ( = 4). Graph presented as mean ± SD representative of three independent experiments. Data were analyzed by one-way ANOVA and posttest (Newman-Keuls Multiple Comparison Test; : control LPS versus CETP group; and : CETP 0.1 versus CETP 1.0).